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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DYRK3
All Species:
26.36
Human Site:
Y441
Identified Species:
41.43
UniProt:
O43781
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43781
NP_001004023.1
588
65714
Y441
E
Q
S
K
R
A
K
Y
F
I
N
S
K
G
I
Chimpanzee
Pan troglodytes
XP_524527
588
65774
Y441
E
Q
S
K
R
A
K
Y
F
I
N
S
K
G
I
Rhesus Macaque
Macaca mulatta
XP_001086117
588
65769
Y441
E
Q
S
K
R
A
K
Y
F
I
N
S
K
G
I
Dog
Lupus familis
XP_537131
637
71340
Y491
E
Q
S
K
R
A
K
Y
F
I
N
S
K
G
L
Cat
Felis silvestris
Mouse
Mus musculus
Q922Y0
586
65553
Y440
E
Q
S
K
R
A
K
Y
F
I
N
S
K
G
L
Rat
Rattus norvegicus
Q4V8A3
586
65492
Y440
E
Q
S
K
R
A
K
Y
F
I
N
S
K
G
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511087
546
60615
N400
D
A
S
K
R
A
K
N
F
V
S
S
K
G
Y
Chicken
Gallus gallus
Q5ZIU3
526
59419
N379
D
S
S
K
R
A
K
N
F
V
S
S
K
G
Y
Frog
Xenopus laevis
NP_001088793
567
63329
N421
E
Q
A
K
R
A
K
N
F
I
N
S
K
G
Y
Zebra Danio
Brachydanio rerio
NP_001108400
581
65351
N432
E
Q
A
K
R
A
K
N
F
I
S
S
K
G
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P83102
828
92722
S508
A
S
S
K
R
S
K
S
F
F
S
P
K
G
Y
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_001023207
817
89866
L670
G
E
D
E
N
D
Q
L
A
L
I
I
E
L
L
Sea Urchin
Strong. purpuratus
XP_799140
561
63192
Q414
E
V
M
G
M
P
S
Q
N
L
I
D
T
S
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51566
467
54180
S324
N
Y
P
C
D
L
W
S
I
G
C
I
L
V
E
Baker's Yeast
Sacchar. cerevisiae
P14680
807
91227
T623
T
Q
K
H
R
M
K
T
I
E
E
F
C
R
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
98.8
85.7
N.A.
89.6
90.8
N.A.
57.9
59
65.3
63.4
N.A.
39
N.A.
40.5
54.7
Protein Similarity:
100
99.4
99.4
88.8
N.A.
93.5
94.2
N.A.
70.7
71.9
77.8
76.6
N.A.
50.9
N.A.
52.5
68.3
P-Site Identity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
60
60
80
73.3
N.A.
46.6
N.A.
0
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
80
80
86.6
86.6
N.A.
60
N.A.
40
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.2
26.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
37.7
41
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
14
0
0
67
0
0
7
0
0
0
0
0
0
% A
% Cys:
0
0
0
7
0
0
0
0
0
0
7
0
7
0
0
% C
% Asp:
14
0
7
0
7
7
0
0
0
0
0
7
0
0
0
% D
% Glu:
60
7
0
7
0
0
0
0
0
7
7
0
7
0
14
% E
% Phe:
0
0
0
0
0
0
0
0
74
7
0
7
0
0
0
% F
% Gly:
7
0
0
7
0
0
0
0
0
7
0
0
0
74
0
% G
% His:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
7
% H
% Ile:
0
0
0
0
0
0
0
0
14
54
14
14
0
0
20
% I
% Lys:
0
0
7
74
0
0
80
0
0
0
0
0
74
0
7
% K
% Leu:
0
0
0
0
0
7
0
7
0
14
0
0
7
7
27
% L
% Met:
0
0
7
0
7
7
0
0
0
0
0
0
0
0
0
% M
% Asn:
7
0
0
0
7
0
0
27
7
0
47
0
0
0
0
% N
% Pro:
0
0
7
0
0
7
0
0
0
0
0
7
0
0
0
% P
% Gln:
0
60
0
0
0
0
7
7
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
80
0
0
0
0
0
0
0
0
7
0
% R
% Ser:
0
14
60
0
0
7
7
14
0
0
27
67
0
7
0
% S
% Thr:
7
0
0
0
0
0
0
7
0
0
0
0
7
0
0
% T
% Val:
0
7
0
0
0
0
0
0
0
14
0
0
0
7
0
% V
% Trp:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
0
0
0
0
0
40
0
0
0
0
0
0
27
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _